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216 Furthermore, a randomized, double-blind, placebo-controlled trial in 65 hemodialysis patients reported that taking 1,200 mg, but not 600 mg, of CoQ10 daily for four months decreased oxidative stress (as indicated by a decrease in F2-isoprostanes)

Mild deficiency causes fatigue and anemia, with indices indicating vitamin B12 deficiency but no neurological symptoms

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These findings suggest that Schwann cells and other accompanying cells that are crucial in supporting optimized peripheral nerve structure and function and in promoting axonal regeneration after nerve transection [87,88] are potential targets of cortistatin, which could act in an autocrine and/or paracrine manner in this context